InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FSTL3

Summary

InnateDB Protein

IDBP-12740.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FSTL3

Protein Name

follistatin-like 3 (secreted glycoprotein)

Synonyms

FLRG; FSRP;

Species

Homo sapiens

Ensembl Protein

ENSP00000166139

InnateDB Gene

IDBG-12738 (FSTL3)

Protein Structure

UniProt Annotation

Function

Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10. {ECO:0000269PubMed:11948405, ECO:0000269PubMed:15451575, ECO:0000269PubMed:15574124, ECO:0000269PubMed:16336961, ECO:0000269PubMed:17868029, ECO:0000269PubMed:17878677}.

Subcellular Localization

Isoform 1: Secreted.Isoform 2: Nucleus. Note=Although alternative initiation has been demonstrated and resulted in different localization, the major source of nuclear FSTL3 appears not to depend on translation initiation at Met-27 according to. {ECO:0000269PubMed:16150905}.

Disease Associations

Note=A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia. Translocation t(11;19)(q13;p13) with CCDN1.

Tissue Specificity

Expressed in a wide range of tissues. {ECO:0000269PubMed:11459787}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001968	fibronectin binding
GO:0005515	protein binding
GO:0048185	activin binding

Biological Process

GO:0001503	ossification
GO:0001822	kidney development
GO:0002244	hematopoietic progenitor cell differentiation
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007283	spermatogenesis
GO:0008584	male gonad development
GO:0022409	positive regulation of cell-cell adhesion
GO:0030324	lung development
GO:0030325	adrenal gland development
GO:0030514	negative regulation of BMP signaling pathway
GO:0032926	negative regulation of activin receptor signaling pathway
GO:0045671	negative regulation of osteoclast differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0071248	cellular response to metal ion
GO:0090101	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005794	Golgi apparatus
GO:0030141	secretory granule
GO:0044306	neuron projection terminus