InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cul2

Summary

InnateDB Protein

IDBP-127757.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cul2

Protein Name

cullin 2

Synonyms

1300003D18Rik; 4932411N15Rik; AI327301; mKIAA4106;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025073

InnateDB Gene

IDBG-127755 (Cul2)

Protein Structure

UniProt Annotation

Function

Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF) (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 389 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	389 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0032403	protein complex binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0016567	protein ubiquitination
GO:0030163	protein catabolic process

Cellular Component

GO:0030891	VCB complex
GO:0031461	cullin-RING ubiquitin ligase complex
GO:0031462	Cul2-RING ubiquitin ligase complex

Protein Structure and Domains

PDB ID

MGI:1918995

InterPro

IPR001373 Cullin, N-terminal
IPR016158 Cullin homology
IPR016159 Cullin repeat-like-containing domain
IPR019559 Cullin protein, neddylation domain

PFAM

PF00888
PF10557

PRINTS

PIRSF

SMART

SM00182
SM00884

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9D4H8

PhosphoSite

PhosphoSite-Q9D4H8

TrEMBL

UniProt Splice Variant

Entrez Gene

71745

UniGene

Mm.291707

RefSeq

MGI ID

MGI Symbol

Cul2

OMIM

CCDS

HPRD

IMGT

EMBL

AK016520 AK160597 BC025902 BC026779 BC027428

GenPept

AAH25902 AAH26779 AAH27428 BAB30283 BAE35903