Version 5.4
Mus musculus Gene: Cul2
Summary
InnateDB Gene IDBG-127755.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cul2
Gene Name cullin 2
Synonyms 1300003D18Rik; 4932411N15Rik; AI327301; mKIAA4106
Species Mus musculus
Ensembl Gene ENSMUSG00000024231
Encoded Proteins
IDBP-127757
cullin 2
IDBP-127759
cullin 2
IDBP-540455
cullin 2
IDBP-535695
cullin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108094:
Gene Information
Type Protein coding
Genomic Location Chromosome 18:3382988-3436377
Strand Forward strand
Band A1
Transcripts
ENSMUST00000025073 ENSMUSP00000025073
ENSMUST00000080089 ENSMUSP00000078988
ENSMUST00000162301 ENSMUSP00000125403
ENSMUST00000161317 ENSMUSP00000123903
ENSMUST00000161852
ENSMUST00000159443
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 389 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 389 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0032403 protein complex binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
GO:0030163 protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0030891 VCB complex
GO:0031461 cullin-RING ubiquitin ligase complex
GO:0031462 Cul2-RING ubiquitin ligase complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000108094
View Gene Order
ENSBTAG00000007133
Not yet available
Pathways
NETPATH
REACTOME
REACT_236645
Class I MHC mediated antigen processing & presentation pathway
REACT_188957
Cellular responses to stress pathway
REACT_199106
Cellular response to hypoxia pathway
REACT_230745
Immune System pathway
REACT_199108
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway
REACT_199109
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
REACT_199115
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_229531
Adaptive Immune System pathway
KEGG
mmu05211
Renal cell carcinoma pathway
mmu04120
Ubiquitin mediated proteolysis pathway
mmu05200
Pathways in cancer pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_120916
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway
REACT_120956
Cellular responses to stress pathway
REACT_75774
Adaptive Immune System pathway
REACT_120815
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
REACT_6900
Immune System pathway
REACT_121311
Cellular response to hypoxia pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
hsa05211
Renal cell carcinoma pathway
hsa04120
Ubiquitin mediated proteolysis pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
hif1apathway
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.291707
RefSeq NM_029402 XM_006526274 XM_006526275
OMIM
CCDS CCDS29032
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca