InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zeb1

Summary

InnateDB Protein

IDBP-127911.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zeb1

Protein Name

zinc finger E-box binding homeobox 1

Synonyms

[delta]EF1; 3110032K11Rik; AREB6; BZP; MEB1; Nil2; TCF-8; Tcf18; Tcf8; Tw; ZEB; Zfhep; Zfhx1a; Zfx1a; Zfx1ha;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025081

InnateDB Gene

IDBG-127909 (Zeb1)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional repressor. Binds to E-box sequences in the immunoglobulin heavy chain enhancer as well as in the regulatory regions of many other tissue-specific genes. Represses E-cadherin promoter and induces an epithelial- mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1 (By similarity). Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs. {ECO:0000250, ECO:0000269PubMed:19935649, ECO:0000269PubMed:20346398}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:20346398}.

Disease Associations

Tissue Specificity

Expressed in the external germinal layer (EGL) and internal granular layer (IGL) of the cerebellum (at protein level). {ECO:0000269PubMed:20346398}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	5 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0070888	E-box binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0007389	pattern specification process
GO:0007417	central nervous system development
GO:0008285	negative regulation of cell proliferation
GO:0010464	regulation of mesenchymal cell proliferation
GO:0014823	response to activity
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
GO:0030857	negative regulation of epithelial cell differentiation
GO:0030900	forebrain development
GO:0031667	response to nutrient levels
GO:0033081	regulation of T cell differentiation in thymus
GO:0045666	positive regulation of neuron differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048513	organ development
GO:0048596	embryonic camera-type eye morphogenesis
GO:0048598	embryonic morphogenesis
GO:0048704	embryonic skeletal system morphogenesis
GO:0048752	semicircular canal morphogenesis
GO:0051150	regulation of smooth muscle cell differentiation
GO:0051216	cartilage development
GO:0071230	cellular response to amino acid stimulus
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:0090103	cochlea morphogenesis