Mus musculus Gene: Zeb1
Summary
InnateDB Gene IDBG-127909.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Zeb1
Gene Name zinc finger E-box binding homeobox 1
Synonyms [delta]EF1; 3110032K11Rik; AREB6; BZP; MEB1; Nil2; TCF-8; Tcf18; Tcf8; Tw; ZEB; Zfhep; Zfhx1a; Zfx1a; Zfx1ha;
Species Mus musculus
Ensembl Gene ENSMUSG00000024238
Encoded Proteins
zinc finger E-box binding homeobox 1
zinc finger E-box binding homeobox 1
zinc finger E-box binding homeobox 1
zinc finger E-box binding homeobox 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000148516:
This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:5591860-5775467
Strand Forward strand
Band A1
Transcripts
ENSMUST00000025081 ENSMUSP00000025081
ENSMUST00000160522
ENSMUST00000159390 ENSMUSP00000124395
ENSMUST00000161295 ENSMUSP00000124507
ENSMUST00000160910 ENSMUSP00000124815
ENSMUST00000162892
ENSMUST00000159477
ENSMUST00000177070
ENSMUST00000175739
ENSMUST00000175925 ENSMUSP00000135125
ENSMUST00000177030
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 5 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0070888 E-box binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0007389 pattern specification process
GO:0007417 central nervous system development
GO:0008285 negative regulation of cell proliferation
GO:0010464 regulation of mesenchymal cell proliferation
GO:0014823 response to activity
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0030857 negative regulation of epithelial cell differentiation
GO:0030900 forebrain development
GO:0031667 response to nutrient levels
GO:0033081 regulation of T cell differentiation in thymus
GO:0045666 positive regulation of neuron differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048513 organ development
GO:0048596 embryonic camera-type eye morphogenesis
GO:0048598 embryonic morphogenesis
GO:0048704 embryonic skeletal system morphogenesis
GO:0048752 semicircular canal morphogenesis
GO:0051150 regulation of smooth muscle cell differentiation
GO:0051216 cartilage development
GO:0071230 cellular response to amino acid stimulus
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0090103 cochlea morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
TGF_beta_Receptor pathway
REACTOME
KEGG
INOH
PID BIOCARTA
Sumoylation as a mechanism to modulate ctbp-dependent gene responses [Biocarta view]
PID NCI
Integrin-linked kinase signaling
Cross-References
SwissProt
TrEMBL H3BJU2
UniProt Splice Variant
Entrez Gene 21417
UniGene Mm.3929 Mm.399694 Mm.408304 Mm.487086 Mm.487317
RefSeq NM_011546 XM_006525768 XM_006525769 XM_006525770 XM_006525771 XM_006525774 XM_006525775 XM_006525776
OMIM
CCDS CCDS29039
HPRD
IMGT
MGI ID MGI:1344313
MGI Symbol Zeb1
EMBL AC127028 AC138619
GenPept
RNA Seq Atlas 21417