InnateDB Protein
|
IDBP-128125.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Wac
|
Protein Name
|
WW domain containing adaptor with coiled-coil
|
Synonyms
|
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000089746
|
InnateDB Gene
|
IDBG-128123 (Wac)
|
Protein Structure
|
|
Function |
Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage (By similarity). Positive regulator of amino acid starvation-induced autophagy (By similarity). May negatively regulate the ubiquitin proteasome pathway (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Nucleus speckle {ECO:0000269PubMed:11827461}. Nucleus {ECO:0000250}. Note=In distinct nuclear speckles. Colocalizes with pre-mRNA processing complexes.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
|
Protein-Protein |
4
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
13 [view]
|
|
|
Molecular Function |
|
Biological Process |
GO:0006351
|
transcription, DNA-templated
|
GO:0006974
|
cellular response to DNA damage stimulus
|
GO:0010390
|
histone monoubiquitination
|
GO:0016239
|
positive regulation of macroautophagy
|
GO:0032435
|
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
|
GO:0044783
|
G1 DNA damage checkpoint
|
GO:0045893
|
positive regulation of transcription, DNA-templated
|
GO:0071894
|
histone H2B conserved C-terminal lysine ubiquitination
|
|
Cellular Component |
|
PDB ID |
MGI:2387357
|
InterPro |
IPR001202
WW domain
|
PFAM |
PF00397
|
PRINTS |
|
PIRSF |
|
SMART |
SM00456
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q924H7
|
PhosphoSite |
PhosphoSite-Q924H7
|
TrEMBL |
E9Q6U6
|
UniProt Splice Variant |
|
Entrez Gene |
225131
|
UniGene |
Mm.490814
|
RefSeq |
NP_001139770
|
MGI ID |
|
MGI Symbol |
Wac
|
OMIM |
|
CCDS |
CCDS50218
|
HPRD |
|
IMGT |
|
EMBL |
AC130718
AC147624
AF320996
AK044675
AK087826
AK156780
AK173274
BC080851
|
GenPept |
AAH80851
AAK73808
BAC32029
BAC40017
BAD32552
BAE33852
|
|
|