InnateDB Protein
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IDBP-128299.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Lifr
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Protein Name
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leukemia inhibitory factor receptor
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Synonyms
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A230075M04Rik; AW061234; LIF;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000064551
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InnateDB Gene
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IDBG-128297 (Lifr)
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Protein Structure
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Function |
Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.
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Subcellular Localization |
Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 2: Secreted.
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Disease Associations |
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Tissue Specificity |
Placenta, liver, kidney, heart, lung, brain, and embryos. The liver may be the primary site of synthesis of the secreted form.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated |
Total |
12
[view]
|
Protein-Protein |
11
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
7 [view]
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Molecular Function |
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Biological Process |
GO:0008284
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positive regulation of cell proliferation
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GO:0038165
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oncostatin-M-mediated signaling pathway
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GO:0048861
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leukemia inhibitory factor signaling pathway
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GO:0070120
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ciliary neurotrophic factor-mediated signaling pathway
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Cellular Component |
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PDB ID |
MGI:96788
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InterPro |
IPR003961
Fibronectin, type III
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PFAM |
PF00041
PF01108
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PRINTS |
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PIRSF |
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SMART |
SM00060
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TIGRFAMs |
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Modification |
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SwissProt |
P42703
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PhosphoSite |
PhosphoSite-P42703
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
16880
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UniGene |
Mm.472667
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RefSeq |
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MGI ID |
2Q7N
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MGI Symbol |
Lifr
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OMIM |
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CCDS |
CCDS27369
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HPRD |
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IMGT |
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EMBL |
BC031929
D17444
D26177
S73495
S73496
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GenPept |
AAC60697
AAC60698
AAH31929
BAA04258
BAA05165
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