InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gdi2

Summary

InnateDB Protein

IDBP-128350.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gdi2

Protein Name

guanosine diphosphate (GDP) dissociation inhibitor 2

Synonyms

GDI-B; Gdi3; GDIB;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000062996

InnateDB Gene

IDBG-128348 (Gdi2)

Protein Structure

UniProt Annotation

Function

Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.

Subcellular Localization

Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005093	Rab GDP-dissociation inhibitor activity
GO:0005097	Rab GTPase activator activity
GO:0005515	protein binding
GO:0031267	small GTPase binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0032851	positive regulation of Rab GTPase activity
GO:0050790	regulation of catalytic activity