Version 5.4
Homo sapiens Protein: PANX2
Summary
InnateDB Protein IDBP-12844.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PANX2
Protein Name pannexin 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000159647
InnateDB Gene IDBG-12842 (PANX2)
Protein Structure
UniProt Annotation
Function Structural component of the gap junctions and the hemichannels. {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255PROSITE-ProRule:PRU00351}. Cell junction, gap junction.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0055077 gap junction hemi-channel activity
Biological Process
GO:0006811 ion transport
GO:0007268 synaptic transmission
GO:0034214 protein hexamerization
Cellular Component
GO:0005886 plasma membrane
GO:0005921 gap junction
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000990 Innexin
PFAM PF00876
PRINTS PR01262
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96RD6
PhosphoSite PhosphoSite-Q96RD6
TrEMBL
UniProt Splice Variant
Entrez Gene 56666
UniGene Hs.610308
RefSeq NP_001153772
HUGO HGNC:8600
OMIM 608421
CCDS CCDS54544
HPRD 09760
IMGT
EMBL AF398510 AF398511 AK299910 AL022328
GenPept AAK91715 AAK91716 BAH13170

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca