Version 5.4
Homo sapiens Gene: PANX2
Summary
InnateDB Gene IDBG-12842.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PANX2
Gene Name pannexin 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000073150
Encoded Proteins
IDBP-12844
pannexin 2
IDBP-238733
pannexin 2
IDBP-295580
pannexin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 1 are abundantly expressed in central nervous system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 1 may form cell type-specific gap junctions with distinct properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:50170731-50180294
Strand Forward strand
Band q13.33
Transcripts
ENST00000159647 ENSP00000159647
ENST00000395842 ENSP00000379183
ENST00000402472 ENSP00000384148
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0015267 channel activity
GO:0055077 gap junction hemi-channel activity
Biological Process
GO:0002931 response to ischemia
GO:0006811 ion transport
GO:0007268 synaptic transmission
GO:0034214 protein hexamerization
GO:0055085 transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005921 gap junction
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000058441
View Gene Order
ENSBTAG00000009297
Not yet available
Pathways
NETPATH
REACTOME
REACT_16970
Electric Transmission Across Gap Junctions pathway
REACT_13685
Neuronal System pathway
REACT_16881
Transmission across Electrical Synapses pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.440092 Hs.610308
RefSeq NM_001160300 NM_052839
HUGO
OMIM
CCDS CCDS14085 CCDS54544
HPRD 09760
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca