InnateDB Protein
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IDBP-128457.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Esco1
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Protein Name
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establishment of cohesion 1 homolog 1 (S. cerevisiae)
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Synonyms
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A930014I12Rik;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000025142
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InnateDB Gene
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IDBG-128455 (Esco1)
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Protein Structure
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Function |
Acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3 (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=Nuclear at interphase, associated with chromosomes during mitosis. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
|
Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1925055
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q69Z69
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PhosphoSite |
PhosphoSite-Q69Z69
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
77805
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UniGene |
Mm.468860
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RefSeq |
NP_001074691
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MGI ID |
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MGI Symbol |
Esco1
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OMIM |
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CCDS |
CCDS37737
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HPRD |
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IMGT |
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EMBL |
AC102441
AK045656
AK049589
AK173297
BC008220
BC151069
BC151077
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GenPept |
AAH08220
AAI51070
AAI51078
BAC32447
BAC33830
BAD32575
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