InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ucn3

Summary

InnateDB Protein

IDBP-128527.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ucn3

Protein Name

urocortin 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000049678

InnateDB Gene

IDBG-128525 (Ucn3)

Protein Structure

UniProt Annotation

Function

Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed in some areas of the brain including the hypothalamus, amygdala, and brainstem, but is not evident in the cerebellum, pituitary, or cerebral cortex; it is also expressed peripherally in small intestine and skin. {ECO:0000269PubMed:11416224}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005184	neuropeptide hormone activity
GO:0005515	protein binding
GO:0051431	corticotropin-releasing hormone receptor 2 binding

Biological Process

GO:0006950	response to stress
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007586	digestion
GO:0009749	response to glucose
GO:0031669	cellular response to nutrient levels
GO:0032024	positive regulation of insulin secretion
GO:0035902	response to immobilization stress
GO:0042594	response to starvation
GO:0045838	positive regulation of membrane potential
GO:0051412	response to corticosterone
GO:0071456	cellular response to hypoxia