InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HMOX2

Summary

InnateDB Protein

IDBP-12857.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HMOX2

Protein Name

heme oxygenase (decycling) 2

Synonyms

HO-2;

Species

Homo sapiens

Ensembl Protein

ENSP00000219700

InnateDB Gene

IDBG-12855 (HMOX2)

Protein Structure

UniProt Annotation

Function

Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.

Subcellular Localization

Microsome. Endoplasmic reticulum.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.

Experimentally validated
Total	56 [view]
Protein-Protein	55 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004392	heme oxygenase (decyclizing) activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0001666	response to hypoxia
GO:0006778	porphyrin-containing compound metabolic process
GO:0006788	heme oxidation
GO:0006879	cellular iron ion homeostasis
GO:0042167	heme catabolic process
GO:0044281	small molecule metabolic process
GO:0055085	transmembrane transport
GO:0055114	oxidation-reduction process