Homo sapiens Gene: HMOX2
Summary
InnateDB Gene IDBG-12855.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HMOX2
Gene Name heme oxygenase (decycling) 2
Synonyms HO-2;
Species Homo sapiens
Ensembl Gene ENSG00000103415
Encoded Proteins
heme oxygenase (decycling) 2
heme oxygenase (decycling) 2
heme oxygenase (decycling) 2
heme oxygenase (decycling) 2
heme oxygenase (decycling) 2
heme oxygenase (decycling) 2
heme oxygenase (decycling) 2
heme oxygenase (decycling) 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Alternative splice variants encoding the same protein have been identified at this locus. [provided by RefSeq, Jul 2008]
Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Several alternatively spliced transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:4474690-4510347
Strand Forward strand
Band p13.3
Transcripts
ENST00000219700 ENSP00000219700
ENST00000398595 ENSP00000381595
ENST00000406590 ENSP00000385100
ENST00000458134 ENSP00000394103
ENST00000414777 ENSP00000391637
ENST00000574594
ENST00000574466 ENSP00000461428
ENST00000575120 ENSP00000460926
ENST00000570622 ENSP00000459203
ENST00000570646 ENSP00000459214
ENST00000570445 ENSP00000458592
ENST00000575129 ENSP00000460992
ENST00000575051 ENSP00000458797
ENST00000572812 ENSP00000459445
ENST00000576827 ENSP00000458824
ENST00000619913 ENSP00000484467
ENST00000619528 ENSP00000484423
ENST00000613539 ENSP00000477572
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
Experimentally validated
Total 56 [view]
Protein-Protein 55 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004392 heme oxygenase (decyclizing) activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0001666 response to hypoxia
GO:0006778 porphyrin-containing compound metabolic process
GO:0006788 heme oxidation
GO:0006879 cellular iron ion homeostasis
GO:0006979 response to oxidative stress
GO:0042167 heme catabolic process
GO:0044281 small molecule metabolic process
GO:0055085 transmembrane transport
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Iron uptake and transport pathway
Heme degradation pathway
Metabolism of porphyrins pathway
Metabolism pathway
KEGG
Porphyrin and chlorophyll metabolism pathway
INOH
PID BIOCARTA
Oxidative stress induced gene expression via nrf2 [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001127204 NM_001127205 NM_001127206 NM_001286267 NM_001286268 NM_001286269 NM_001286270 NM_001286271 NM_002134
HUGO
OMIM
CCDS CCDS10517 CCDS66931 CCDS73818
HPRD 00783
IMGT
EMBL
GenPept
RNA Seq Atlas