InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gdf6

Summary

InnateDB Protein

IDBP-129107.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gdf6

Protein Name

growth differentiation factor 6

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000062884

InnateDB Gene

IDBG-129105 (Gdf6)

Protein Structure

UniProt Annotation

Function

Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Required for normal formation of bones and joints in the limbs, skull, and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. May signal through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A. {ECO:0000269PubMed:12606286, ECO:0000269PubMed:16049014, ECO:0000269PubMed:23307924}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in different subsets of developing joints. {ECO:0000269PubMed:12606286}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0008083	growth factor activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0006915	apoptotic process
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0030509	BMP signaling pathway
GO:0032924	activin receptor signaling pathway
GO:0040007	growth
GO:0045666	positive regulation of neuron differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060389	pathway-restricted SMAD protein phosphorylation
GO:1990009	retinal cell apoptotic process

Cellular Component

GO:0005615

extracellular space

Protein Structure and Domains

PDB ID

MGI:95689

InterPro

IPR001111 Transforming growth factor-beta, N-terminal
IPR001839 Transforming growth factor-beta, C-terminal
IPR002405 Inhibin, alpha subunit
IPR029034 Cystine-knot cytokine

PFAM

PF00688
PF00019

PRINTS

PR00669

PIRSF

SMART

SM00204

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt