InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TMED10

Summary

InnateDB Protein

IDBP-12917.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TMED10

Protein Name

transmembrane emp24-like trafficking protein 10 (yeast)

Synonyms

p23; P24(DELTA); S31I125; S31III125; Tmp-21-I; TMP21;

Species

Homo sapiens

Ensembl Protein

ENSP00000303145

InnateDB Gene

IDBG-12915 (TMED10)

Protein Structure

UniProt Annotation

Function

Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1 (By similarity). In COPI vesicle-mediated retrograde transport involved in the biogenesis of COPI vesicles and vesicle coat recruitment. On Golgi membranes, acts as primary receptor for ARF1-GDP which is involved in COPI-vesicle formation. Increases coatomer-dependent GTPase-activating activity of ARFGAP2. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2LR1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent of modulation of gamma-secretase activity). As part of the presenilin-dependent gamma-secretase complex regulates gamma-cleavages of the amyloid beta A4 protein to yield amyloid-beta 40 (Abeta40). Involved in organization of the Golgi apparatus. {ECO:0000250, ECO:0000269PubMed:10052452, ECO:0000269PubMed:11726511, ECO:0000269PubMed:16641999, ECO:0000269PubMed:17288597, ECO:0000269PubMed:19296914, ECO:0000269PubMed:20427317, ECO:0000269PubMed:21219331}.

Subcellular Localization

Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Melanosome. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Cycles between compartments of the early secretatory pathway.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	31 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019905	syntaxin binding
GO:0032403	protein complex binding

Biological Process

GO:0001822	kidney development
GO:0006810	transport
GO:0006886	intracellular protein transport
GO:0006888	ER to Golgi vesicle-mediated transport
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER
GO:0007030	Golgi organization
GO:0034205	beta-amyloid formation
GO:0035459	cargo loading into vesicle
GO:0035964	COPI-coated vesicle budding
GO:0043279	response to alkaloid
GO:0045055	regulated secretory pathway
GO:0048199	vesicle targeting, to, from or within Golgi
GO:0048205	COPI coating of Golgi vesicle
GO:0048208	COPII vesicle coating
GO:0051259	protein oligomerization

Cellular Component

GO:0000139	Golgi membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005794	Golgi apparatus
GO:0005801	cis-Golgi network
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030137	COPI-coated vesicle
GO:0030140	trans-Golgi network transport vesicle
GO:0030658	transport vesicle membrane
GO:0030667	secretory granule membrane
GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0042470	melanosome
GO:0042589	zymogen granule membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome
GO:0070765	gamma-secretase complex