InnateDB Protein
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IDBP-129397.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Rad1
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Protein Name
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RAD1 homolog (S. pombe)
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Synonyms
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mRAD1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000098338
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InnateDB Gene
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IDBG-129395 (Rad1)
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Protein Structure
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Function |
Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. Isoform 1 possesses 3'->5' double stranded DNA exonuclease activity (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in testis, uterus, bladder, spleen, ovaries, lung, brain and muscle (at protein level). Expressed in brain, testis, kidney, heart, liver and lung. {ECO:0000269PubMed:9660799, ECO:0000269PubMed:9716408, ECO:0000269PubMed:9828137}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
18 [view]
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Molecular Function |
Accession |
GO Term |
GO:0008408
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3'-5' exonuclease activity
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GO:0008853
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exodeoxyribonuclease III activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1316678
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InterPro |
IPR003011
Cell cycle checkpoint protein, Rad1
IPR003021
Rad1/Rec1/Rad17
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PFAM |
PF02144
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PRINTS |
PR01246
PR01245
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9QWZ1
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PhosphoSite |
PhosphoSite-
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TrEMBL |
E9PXK0
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UniProt Splice Variant |
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Entrez Gene |
19355
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UniGene |
Mm.38376
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RefSeq |
NP_001276377
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MGI ID |
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MGI Symbol |
Rad1
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OMIM |
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CCDS |
CCDS70618
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HPRD |
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IMGT |
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EMBL |
AC102101
AF038841
AF058394
AF073523
AF074718
AF076842
AF084514
AJ004976
AK146533
AK148098
AK150466
AK168588
BC048693
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GenPept |
AAC14139
AAC27248
AAC35551
AAC95465
AAC95524
AAC98094
AAH48693
BAE27240
BAE28343
BAE29583
BAE40457
CAA06250
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