InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rad1

Summary

InnateDB Protein

IDBP-129399.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rad1

Protein Name

RAD1 homolog (S. pombe)

Synonyms

mRAD1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022856

InnateDB Gene

IDBG-129395 (Rad1)

Protein Structure

UniProt Annotation

Function

Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. Isoform 1 possesses 3'->5' double stranded DNA exonuclease activity (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in testis, uterus, bladder, spleen, ovaries, lung, brain and muscle (at protein level). Expressed in brain, testis, kidney, heart, liver and lung. {ECO:0000269PubMed:9660799, ECO:0000269PubMed:9716408, ECO:0000269PubMed:9828137}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008408	3'-5' exonuclease activity
GO:0008853	exodeoxyribonuclease III activity

Biological Process

GO:0000077	DNA damage checkpoint
GO:0000738	DNA catabolic process, exonucleolytic
GO:0006281	DNA repair
GO:0021762	substantia nigra development
GO:0071479	cellular response to ionizing radiation
GO:0090305	nucleic acid phosphodiester bond hydrolysis