InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Aass

Summary

InnateDB Protein

IDBP-129692.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aass

Protein Name

aminoadipate-semialdehyde synthase

Synonyms

LKR; LKR/SDH; LOR; LOR/SDH; Lorsdh; SDH;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031707

InnateDB Gene

IDBG-129690 (Aass)

Protein Structure

UniProt Annotation

Function

Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-oxoglutarate reductase and saccharopine dehydrogenase activity, respectively.

Subcellular Localization

Mitochondrion.

Disease Associations

Tissue Specificity

Both enzymes are highly expressed in kidney and liver, very low expression is seen in heart, brain, spleen, lung, skeletal muscle and testis. SDH was detected only in cortical regions of the kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016491	oxidoreductase activity
GO:0047130	saccharopine dehydrogenase (NADP+, L-lysine-forming) activity
GO:0047131	saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity

Biological Process

GO:0006091	generation of precursor metabolites and energy
GO:0019477	L-lysine catabolic process
GO:0033512	L-lysine catabolic process to acetyl-CoA via saccharopine
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

MGI:1353573

InterPro

IPR005097 Saccharopine dehydrogenase / Homospermidine synthase
IPR007698 Alanine dehydrogenase/PNT, NAD(H)-binding domain
IPR007886 Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal

PFAM

PF03435
PF01262
PF05222

PRINTS

PIRSF

SMART

SM01002
SM01003

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99K67