Version 5.4
Mus musculus Gene: Aass
Summary
InnateDB Gene IDBG-129690.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Aass
Gene Name aminoadipate-semialdehyde synthase
Synonyms LKR; LKR/SDH; LOR; LOR/SDH; Lorsdh; SDH
Species Mus musculus
Ensembl Gene ENSMUSG00000029695
Encoded Proteins
IDBP-129692
aminoadipate-semialdehyde synthase
IDBP-538589
aminoadipate-semialdehyde synthase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a bifunctional mitochondrial protein that catalyzes the first two steps in the lysine degradation pathway. The N-terminus contains lysine-ketoglutarate reductase activity and converts lysine to saccharopine, whereas the C-terminus contains saccharopine dehydrogenase activity and converts saccharopine to alpha-aminoadipate semialdehyde. Mutations in a human gene encoding a highly similar protein are associated with familial hyperlysinemia. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:23072173-23132986
Strand Reverse strand
Band A3.1
Transcripts
ENSMUST00000031707 ENSMUSP00000031707
ENSMUST00000149864 ENSMUSP00000115079
ENSMUST00000138063
ENSMUST00000152280
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016491 oxidoreductase activity
GO:0047130 saccharopine dehydrogenase (NADP+, L-lysine-forming) activity
GO:0047131 saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0019477 L-lysine catabolic process
GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000008311
View Gene Order
ENSBTAG00000012128
Not yet available
Pathways
NETPATH
REACTOME
REACT_188937
Metabolism pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
REACT_239844
Lysine catabolism pathway
KEGG
mmu00310
Lysine degradation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1298
Lysine catabolism pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00310
Lysine degradation pathway
INOH
INOH website
Lysine degradation pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.18651
RefSeq NM_013930
OMIM
CCDS CCDS19937
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca