Version 5.4
Mus musculus Protein: Ttr
Summary
InnateDB Protein IDBP-130238.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ttr
Protein Name transthyretin
Synonyms AA408768; AI787086; D17860; prealbumin;
Species Mus musculus
Ensembl Protein ENSMUSP00000074783
InnateDB Gene IDBG-130236 (Ttr)
Protein Structure
UniProt Annotation
Function Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Detected in plasma (at protein level). Detected in liver.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 4 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 45 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0042562 hormone binding
GO:0042802 identical protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006810 transport
GO:0042572 retinol metabolic process
Cellular Component
GO:0005615 extracellular space
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:98865
InterPro IPR000895 Transthyretin/hydroxyisourate hydrolase
IPR023416 Transthyretin/hydroxyisourate hydrolase, superfamily
PFAM PF00576
PRINTS PR00189
PIRSF
SMART SM00095
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P07309
PhosphoSite PhosphoSite-P07309
TrEMBL Q5M9K1
UniProt Splice Variant
Entrez Gene 22139
UniGene Mm.470364
RefSeq NP_038725
MGI ID 2QPF
MGI Symbol Ttr
OMIM
CCDS CCDS29085
HPRD
IMGT
EMBL AK018701 AK050155 AK075588 BC024702 BC086926 CH466557 D00073 D89076 X03351
GenPept AAH24702 AAH86926 BAA00050 BAA13757 BAB31352 BAC34098 BAC35839 CAA27057 EDK96952

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca