InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Porcn

Summary

InnateDB Protein

IDBP-130307.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Porcn

Protein Name

porcupine homolog (Drosophila)

Synonyms

2410004O13Rik; AW045557; DXHXS7465e; mMg61; Mporc; Mporc-a; Mporc-b; Mporc-c; Mporc-d; porc; Ppn;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000086825

InnateDB Gene

IDBG-130301 (Porcn)

Protein Structure

UniProt Annotation

Function

protein-cysteine N-palmitoyltransferase that modulates the processing of Wnt proteins by mediating serine palmitoylation of Wnt family members. {ECO:0000269PubMed:10866835, ECO:0000269PubMed:22046319}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:10866835}; Multi-pass membrane protein {ECO:0000269PubMed:10866835}.

Disease Associations

Tissue Specificity

Expressed in brain, heart, kidney, liver, lung, muscle, spleen and testis. Isoform 4 is strongly expressed in kidney, liver, lung, spleen and testis. Isoform 1 is strongly expressed in brain, heart and muscle and poorly in kidney, liver, lung, spleen and testis. {ECO:0000269PubMed:10866835}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	18 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016746	transferase activity, transferring acyl groups

Biological Process

GO:0009100	glycoprotein metabolic process
GO:0016055	Wnt signaling pathway

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0030176	integral component of endoplasmic reticulum membrane
GO:0032281	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex