InnateDB Protein
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IDBP-130309.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Porcn
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Protein Name
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porcupine homolog (Drosophila)
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Synonyms
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2410004O13Rik; AW045557; DXHXS7465e; mMg61; Mporc; Mporc-a; Mporc-b; Mporc-c; Mporc-d; porc; Ppn;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000086824
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InnateDB Gene
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IDBG-130301 (Porcn)
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Protein Structure
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Function |
protein-cysteine N-palmitoyltransferase that modulates the processing of Wnt proteins by mediating serine palmitoylation of Wnt family members. {ECO:0000269PubMed:10866835, ECO:0000269PubMed:22046319}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000269PubMed:10866835}; Multi-pass membrane protein {ECO:0000269PubMed:10866835}.
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Disease Associations |
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Tissue Specificity |
Expressed in brain, heart, kidney, liver, lung, muscle, spleen and testis. Isoform 4 is strongly expressed in kidney, liver, lung, spleen and testis. Isoform 1 is strongly expressed in brain, heart and muscle and poorly in kidney, liver, lung, spleen and testis. {ECO:0000269PubMed:10866835}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
19
[view]
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Protein-Protein |
18
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005515
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protein binding
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GO:0016746
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transferase activity, transferring acyl groups
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Biological Process |
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Cellular Component |
GO:0005789
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endoplasmic reticulum membrane
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GO:0030176
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integral component of endoplasmic reticulum membrane
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GO:0032281
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alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
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PDB ID |
MGI:1890212
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InterPro |
IPR004299
Membrane bound O-acyl transferase, MBOAT
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PFAM |
PF03062
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9JJJ7
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
53627
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UniGene |
Mm.443425
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RefSeq |
NP_058609
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MGI ID |
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MGI Symbol |
Porcn
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OMIM |
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CCDS |
CCDS29990
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HPRD |
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IMGT |
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EMBL |
AB036746
AB036747
AB036748
AB036749
AK010405
AL663032
BC032284
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GenPept |
AAH32284
BAA89467
BAA89468
BAA89469
BAA89470
BAB26914
CAM19505
CAM19507
CAM19508
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