InnateDB Protein
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IDBP-130675.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Stmn2
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Protein Name
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stathmin-like 2
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Synonyms
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AI159727; SCG10; Scgn10; Stmb2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000029002
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InnateDB Gene
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IDBG-130673 (Stmn2)
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Protein Structure
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Function |
Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone. {ECO:0000269PubMed:21297631}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:16618812}. Cytoplasm, perinuclear region {ECO:0000269PubMed:16618812}. Cell projection, growth cone {ECO:0000269PubMed:16618812}. Cell projection, axon {ECO:0000269PubMed:16618812}. Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Endosome {ECO:0000250}. Golgi apparatus {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Note=Colocalized with CIB1 in neurites of developing hippocampal primary neurons. Colocalized with CIB1 in the cell body, neuritis, growth cones of neurons and in neurites of developing hippocampal primary neurons. Colocalized with CIB1 to the leading edge of lamellipodia (By similarity). Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. Exists in both soluble and membrane-bound forms. In the developing brain, mostly cytosolic. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Neuron specific.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
23 [view]
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Molecular Function |
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Biological Process |
GO:0007026
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negative regulation of microtubule depolymerization
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GO:0010976
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positive regulation of neuron projection development
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GO:0010977
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negative regulation of neuron projection development
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GO:0031110
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regulation of microtubule polymerization or depolymerization
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GO:0031115
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negative regulation of microtubule polymerization
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GO:0031117
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positive regulation of microtubule depolymerization
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GO:1990090
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cellular response to nerve growth factor stimulus
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Cellular Component |
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PDB ID |
MGI:98241
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InterPro |
IPR000956
Stathmin family
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PFAM |
PF00836
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PRINTS |
PR00345
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PIRSF |
PIRSF002285
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P55821
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PhosphoSite |
PhosphoSite-P55821
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TrEMBL |
Q545S4
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UniProt Splice Variant |
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Entrez Gene |
20257
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UniGene |
Mm.409993
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RefSeq |
NP_079561
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MGI ID |
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MGI Symbol |
Stmn2
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OMIM |
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CCDS |
CCDS17231
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HPRD |
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IMGT |
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EMBL |
AK003659
AK149212
BC026538
CH466577
L20259
L20260
L20261
L20262
L20263
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GenPept |
AAH26538
BAB22921
BAE28766
EDL05200
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