InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Klf11

Summary

InnateDB Protein

IDBP-131109.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Klf11

Protein Name

Kruppel-like factor 11

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020982

InnateDB Gene

IDBG-131107 (Klf11)

Protein Structure

UniProt Annotation

Function

Transcription factor. Activates the epsilon- and gamma- globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding sites inhibiting cell growth (By similarity). Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis. {ECO:0000250UniProtKB:O14901, ECO:0000269PubMed:14697507, ECO:0000269PubMed:18189266}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006915	apoptotic process
GO:0008285	negative regulation of cell proliferation
GO:0043065	positive regulation of apoptotic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:1901653	cellular response to peptide