Version 5.4
Mus musculus Gene: Klf11
Summary
InnateDB Gene IDBG-131107.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Klf11
Gene Name Kruppel-like factor 11
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000020653
Encoded Proteins
IDBP-131109
Kruppel-like factor 11
IDBP-541840
Kruppel-like factor 11
IDBP-539838
Kruppel-like factor 11
IDBP-535590
Kruppel-like factor 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000172059:
The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:24651371-24662774
Strand Forward strand
Band A1.3
Transcripts
ENSMUST00000020982 ENSMUSP00000020982
ENSMUST00000146894 ENSMUSP00000115340
ENSMUST00000139940 ENSMUSP00000118623
ENSMUST00000144046 ENSMUSP00000121730
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0044212 transcription regulatory region DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006915 apoptotic process
GO:0008285 negative regulation of cell proliferation
GO:0043065 positive regulation of apoptotic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:1901653 cellular response to peptide
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000172059
View Gene Order
ENSBTAG00000046218
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8K1S5
TrEMBL D3YZX6 D3Z0S4 D3Z293
UniProt Splice Variant
Entrez Gene 194655
UniGene Mm.9616
RefSeq NM_178357
OMIM
CCDS CCDS25842
HPRD
IMGT
MGI ID MGI:2653368
MGI Symbol Klf11
EMBL AC140262 AJ459773 AK036618 AK038397 AK050156 AK054170 AK082838 AK084913 AK089044 AK161233 BC060642
GenPept AAH60642 BAC29509 BAC29984 BAC34099 BAC35678 BAC38647 BAC39307 BAC40717 BAE36256 CAD30835
RNA Seq Atlas 194655

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca