InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dnase1l3

Summary

InnateDB Protein

IDBP-131493.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dnase1l3

Protein Name

deoxyribonuclease 1-like 3

Synonyms

Dhp2; DNasegamma; Lsd;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026315

InnateDB Gene

IDBG-131491 (Dnase1l3)

Protein Structure

UniProt Annotation

Function

Has DNA hydrolytic activity. Does not bind to actin.

Subcellular Localization

Nucleus {ECO:0000250}. Note=May first pass through the ER membrane before being imported in the nucleus. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed at high levels in liver and spleen.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004519	endonuclease activity
GO:0004520	endodeoxyribonuclease activity
GO:0004536	deoxyribonuclease activity
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters

Biological Process

GO:0006308	DNA catabolic process
GO:0006309	apoptotic DNA fragmentation
GO:0010623	developmental programmed cell death

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:1314633

InterPro

IPR005135 Endonuclease/exonuclease/phosphatase
IPR016202 Deoxyribonuclease I

PFAM

PF03372
PF14529

PRINTS

PR00130

PIRSF

PIRSF000988

SMART

SM00476

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O55070

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

13421

UniGene

Mm.490513

RefSeq

NP_031896

MGI ID

MGI Symbol

Dnase1l3

OMIM

CCDS

CCDS26807

HPRD

IMGT

EMBL

AF047355 AY024355 BC012671 U76110

GenPept

AAC35753 AAD09222 AAH12671 AAK07733