Version 5.4
Mus musculus Gene: Dnase1l3
Summary
InnateDB Gene IDBG-131491.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dnase1l3
Gene Name deoxyribonuclease 1-like 3
Synonyms Dhp2; DNasegamma; Lsd
Species Mus musculus
Ensembl Gene ENSMUSG00000025279
Encoded Proteins
IDBP-131493
deoxyribonuclease 1-like 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163687:
This gene encodes a member of the deoxyribonuclease I family. The encoded protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Mutations in this gene are a cause of systemic lupus erythematosus-16. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:7964533-7994573
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000026315 ENSMUSP00000026315
ENSMUST00000145234
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004519 endonuclease activity
GO:0004520 endodeoxyribonuclease activity
GO:0004536 deoxyribonuclease activity
GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters
Biological Process
GO:0006308 DNA catabolic process
GO:0006309 apoptotic DNA fragmentation
GO:0010623 developmental programmed cell death
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000163687
View Gene Order
ENSBTAG00000018294
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.272258 Mm.490513
RefSeq NM_007870 XM_006517921
OMIM
CCDS CCDS26807
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca