InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rgs20

Summary

InnateDB Protein

IDBP-131722.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rgs20

Protein Name

regulator of G-protein signaling 20

Synonyms

2900073E09Rik; Rgsz1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000002533

InnateDB Gene

IDBG-131720 (Rgs20)

Protein Structure

UniProt Annotation

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G- protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins. {ECO:0000269PubMed:14997173, ECO:0000269PubMed:15827571, ECO:0000269PubMed:16900103}.

Subcellular Localization

Membrane; Lipid-anchor. Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm/cell membrane and the nucleus Anchored to the membrane through palmitoylation. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043547	positive regulation of GTPase activity