InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pde7a

Summary

InnateDB Protein

IDBP-132474.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pde7a

Protein Name

phosphodiesterase 7A

Synonyms

AU015378; AW047537;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000088863

InnateDB Gene

IDBG-132472 (Pde7a)

Protein Structure

UniProt Annotation

Function

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Widely expressed with highest levels in the skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity
GO:0046872	metal ion binding

Biological Process

GO:0006198	cAMP catabolic process
GO:0007165	signal transduction
GO:0008152	metabolic process

Cellular Component

Protein Structure and Domains

PDB ID

MGI:1202402

InterPro

IPR002073 3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR003607 HD/PDEase domain
IPR023088 3\'5\'-cyclic nucleotide phosphodiesterase

PFAM

PF00233

PRINTS

PR00387

PIRSF

SMART

SM00471

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt