Mus musculus Protein: Birc2
InnateDB Protein IDBP-133127.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Birc2
Protein Name baculoviral IAP repeat-containing 2
Synonyms Api1; Api2; AW146227; Birc3; cIAP1; cIAP2; HIAP1; HIAP2; IAP1; IAP2; mcIAP1; MIAP1; MIAP2; MIHB; MIHC; RNF48;
Species Mus musculus
Ensembl Protein ENSMUSP00000091422
InnateDB Gene IDBG-133125 (Birc2)
Protein Structure
UniProt Annotation
Function Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin- protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase- dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle. {ECO:0000269PubMed:18621737}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Agents that induce either the extrinsic or intrinsic apoptotic pathways promote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with the midbody in telophase cells, and found diffusely in the nucleus of interphase cells (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 105 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
Predicted by orthology
Total 105 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0047485 protein N-terminus binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0001666 response to hypoxia
GO:0001890 placenta development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006915 apoptotic process
GO:0042981 regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087 innate immune response (InnateDB)
GO:0045471 response to ethanol
GO:0051291 protein heterooligomerization
GO:0051591 response to cAMP
GO:0051726 regulation of cell cycle
GO:0060546 negative regulation of necroptotic process
GO:0070266 necroptotic process
GO:1902443 negative regulation of ripoptosome assembly involved in necroptotic process
GO:1902523 positive regulation of protein K63-linked ubiquitination
GO:1902524 positive regulation of protein K48-linked ubiquitination
GO:1902527 positive regulation of protein monoubiquitination
GO:2000377 regulation of reactive oxygen species metabolic process
Cellular Component
GO:0001741 XY body
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0009898 cytoplasmic side of plasma membrane
GO:0035631 CD40 receptor complex
GO:0045121 membrane raft
Protein Structure and Domains
PDB ID MGI:1197009
InterPro IPR001315 CARD domain
IPR001370 Baculoviral inhibition of apoptosis protein repeat
IPR001841 Zinc finger, RING-type
IPR011029 Death-like domain
PFAM PF00619
Post-translational Modifications
SwissProt Q62210
PhosphoSite PhosphoSite-Q62210
UniProt Splice Variant
Entrez Gene 11797
UniGene Mm.335659
RefSeq NP_031491
MGI Symbol Birc2
EMBL BC145985 L49433 U88909
GenPept AAC42078 AAC53532 AAI45986