InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Birc2

Summary

InnateDB Protein

IDBP-133127.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Birc2

Protein Name

baculoviral IAP repeat-containing 2

Synonyms

Api1; Api2; AW146227; Birc3; cIAP1; cIAP2; HIAP1; HIAP2; IAP1; IAP2; mcIAP1; MIAP1; MIAP2; MIHB; MIHC; RNF48;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000091422

InnateDB Gene

IDBG-133125 (Birc2)

Protein Structure

UniProt Annotation

Function

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin- protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase- dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle. {ECO:0000269PubMed:18621737}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Agents that induce either the extrinsic or intrinsic apoptotic pathways promote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with the midbody in telophase cells, and found diffusely in the nucleus of interphase cells (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 105 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	105 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0047485	protein N-terminus binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0001666	response to hypoxia
GO:0001890	placenta development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006915	apoptotic process
GO:0042981	regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045471	response to ethanol
GO:0051291	protein heterooligomerization
GO:0051591	response to cAMP
GO:0051726	regulation of cell cycle
GO:0060546	negative regulation of necroptotic process
GO:0070266	necroptotic process
GO:1902443	negative regulation of ripoptosome assembly involved in necroptotic process
GO:1902523	positive regulation of protein K63-linked ubiquitination
GO:1902524	positive regulation of protein K48-linked ubiquitination
GO:1902527	positive regulation of protein monoubiquitination
GO:2000377	regulation of reactive oxygen species metabolic process

Cellular Component

GO:0001741	XY body
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0009898	cytoplasmic side of plasma membrane
GO:0035631	CD40 receptor complex
GO:0045121	membrane raft