InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Birc2

Summary

InnateDB Gene

IDBG-133125.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Birc2

Gene Name

baculoviral IAP repeat-containing 2

Synonyms

Api1; Api2; AW146227; Birc3; cIAP1; cIAP2; HIAP1; HIAP2; IAP1; IAP2; mcIAP1; MIAP1; MIAP2; MIHB; MIHC; RNF48

Species

Mus musculus

Ensembl Gene

ENSMUSG00000057367

Encoded Proteins

IDBP-133127

baculoviral IAP repeat-containing 2

IDBP-789532

baculoviral IAP repeat-containing 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21447281

Birc2 facilitates ubiquitin-dependent signalling activated by pattern recognition receptors, such as TLR and NOD, to mediate the activation of NFKB transcription.

InnateDB Annotation from Orthologs

Summary

PMID 18697935

[Homo sapiens] BIRC2 regulates TNF-alpha(TNF)-mediated NF-kappaB activation by binding to TNFRSF1A (TNF receptor 1).

PMID 17220297

[Homo sapiens] BIRC2 is the ubiquitin protein ligase for ASK1 ubiquitination, a protein that plays an essential role in tumour necrosis factor alpha (TNF-alpha)-induced mitogen-activated protein kinase signalling. BIRC2 is also responsible for regulating the duration of TNF signalling in primary cells expressing TNFR2.

PMID 19464198

[Homo sapiens] BIRC2 and BIRC3 are required for innate immunity signalling by the pattern recognition receptors NOD1 and NOD2.

PMID 20458734

[Homo sapiens] BIRC2 plays a role in lipopolysaccharide (LPS)-induced autophagy in vascular endothelial cells (VECs).

PMID 21447281

[Homo sapiens] BIRC2 facilitates ubiquitin-dependent signalling activated by pattern recognition receptors, such as TLR and NOD, to mediate the activation of NFKB transcription.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110330:
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:7818227-7837064

Strand

Reverse strand

Band

Transcripts

ENSMUST00000074246	ENSMUSP00000091422
ENSMUST00000190341	ENSMUSP00000140049
ENSMUST00000191248
ENSMUST00000189935

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 105 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	105 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0003713	transcription coactivator activity
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0047485	protein N-terminus binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0001666	response to hypoxia
GO:0001890	placenta development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006915	apoptotic process
GO:0008150	biological_process
GO:0010243	response to organonitrogen compound
GO:0014070	response to organic cyclic compound
GO:0042981	regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045471	response to ethanol
GO:0051291	protein heterooligomerization
GO:0051591	response to cAMP
GO:0051726	regulation of cell cycle
GO:0060544	regulation of necroptotic process
GO:0060546	negative regulation of necroptotic process
GO:0070266	necroptotic process
GO:1902443	negative regulation of ripoptosome assembly involved in necroptotic process
GO:1902523	positive regulation of protein K63-linked ubiquitination
GO:1902524	positive regulation of protein K48-linked ubiquitination
GO:1902527	positive regulation of protein monoubiquitination
GO:2000377	regulation of reactive oxygen species metabolic process

Cellular Component

GO:0001741	XY body
GO:0005575	cellular_component
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0009898	cytoplasmic side of plasma membrane
GO:0035631	CD40 receptor complex
GO:0043234	protein complex
GO:0045121	membrane raft