Mus musculus Gene: Birc2
Summary
InnateDB Gene IDBG-133125.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Birc2
Gene Name baculoviral IAP repeat-containing 2
Synonyms Api1; Api2; AW146227; Birc3; cIAP1; cIAP2; HIAP1; HIAP2; IAP1; IAP2; mcIAP1; MIAP1; MIAP2; MIHB; MIHC; RNF48;
Species Mus musculus
Ensembl Gene ENSMUSG00000057367
Encoded Proteins
baculoviral IAP repeat-containing 2
baculoviral IAP repeat-containing 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Birc2 facilitates ubiquitin-dependent signalling activated by pattern recognition receptors, such as TLR and NOD, to mediate the activation of NFKB transcription.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] BIRC2 regulates TNF-alpha(TNF)-mediated NF-kappaB activation by binding to TNFRSF1A (TNF receptor 1).
[Homo sapiens] BIRC2 is the ubiquitin protein ligase for ASK1 ubiquitination, a protein that plays an essential role in tumour necrosis factor alpha (TNF-alpha)-induced mitogen-activated protein kinase signalling. BIRC2 is also responsible for regulating the duration of TNF signalling in primary cells expressing TNFR2.
[Homo sapiens] BIRC2 and BIRC3 are required for innate immunity signalling by the pattern recognition receptors NOD1 and NOD2.
[Homo sapiens] BIRC2 plays a role in lipopolysaccharide (LPS)-induced autophagy in vascular endothelial cells (VECs).
[Homo sapiens] BIRC2 facilitates ubiquitin-dependent signalling activated by pattern recognition receptors, such as TLR and NOD, to mediate the activation of NFKB transcription.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110330:
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:7818227-7837064
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000074246 ENSMUSP00000091422
ENSMUST00000190341 ENSMUSP00000140049
ENSMUST00000191248
ENSMUST00000189935
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 105 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 105 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003713 transcription coactivator activity
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0047485 protein N-terminus binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0001666 response to hypoxia
GO:0001890 placenta development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006915 apoptotic process
GO:0008150 biological_process
GO:0010243 response to organonitrogen compound
GO:0014070 response to organic cyclic compound
GO:0042981 regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087 innate immune response (InnateDB)
GO:0045471 response to ethanol
GO:0051291 protein heterooligomerization
GO:0051591 response to cAMP
GO:0051726 regulation of cell cycle
GO:0060544 regulation of necroptotic process
GO:0060546 negative regulation of necroptotic process
GO:0070266 necroptotic process
GO:1902443 negative regulation of ripoptosome assembly involved in necroptotic process
GO:1902523 positive regulation of protein K63-linked ubiquitination
GO:1902524 positive regulation of protein K48-linked ubiquitination
GO:1902527 positive regulation of protein monoubiquitination
GO:2000377 regulation of reactive oxygen species metabolic process
Cellular Component
GO:0001741 XY body
GO:0005575 cellular_component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0009898 cytoplasmic side of plasma membrane
GO:0035631 CD40 receptor complex
GO:0043234 protein complex
GO:0045121 membrane raft
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Toll Like Receptor 3 (TLR3) Cascade pathway
Innate Immune System pathway
Apoptosis pathway
Apoptotic cleavage of cellular proteins pathway
Immune System pathway
Toll-Like Receptors Cascades pathway
Activated TLR4 signalling pathway
IKK complex recruitment mediated by RIP1 pathway
MyD88-independent cascade pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Apoptotic execution phase pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
Ubiquitin mediated proteolysis pathway
Apoptosis pathway
Focal adhesion pathway
NOD-like receptor signaling pathway pathway
Toxoplasmosis pathway
Pathways in cancer pathway
Small cell lung cancer pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
TNFalpha pathway
TWEAK pathway
REACTOME
Apoptotic execution phase pathway
Innate Immune System pathway
IKK complex recruitment mediated by RIP1 pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Toll-Like Receptors Cascades pathway
Apoptosis pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
NOD1/2 Signaling Pathway pathway
Apoptotic cleavage of cellular proteins pathway
Immune System pathway
MyD88-independent cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Activated TLR4 signalling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
KEGG
Ubiquitin mediated proteolysis pathway
Apoptosis pathway
Focal adhesion pathway
NOD-like receptor signaling pathway pathway
Toxoplasmosis pathway
Pathways in cancer pathway
Small cell lung cancer pathway
INOH
PID BIOCARTA
Role of mitochondria in apoptotic signaling [Biocarta view]
Keratinocyte differentiation [Biocarta view]
Hiv-1 nef: negative effector of fas and tnf [Biocarta view]
Caspase cascade in apoptosis [Biocarta view]
PID NCI
CD40/CD40L signaling
TNF receptor signaling pathway
Canonical NF-kappaB pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.335659
RefSeq NM_007465 XM_006509833 XM_006509834 XM_006509835
OMIM
CCDS CCDS22811
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas