InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc26a3

Summary

InnateDB Protein

IDBP-133144.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc26a3

Protein Name

solute carrier family 26, member 3

Synonyms

9030623B18Rik; 9130013M11Rik; AV376035; Dra;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000001254

InnateDB Gene

IDBG-133142 (Slc26a3)

Protein Structure

UniProt Annotation

Function

Chloride/bicarbonate exchanger. Mediates the efficient absorption of chloride ions in the colon, participating in fluid homeostasis. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation. {ECO:0000269PubMed:10428871, ECO:0000269PubMed:21976599}.

Subcellular Localization

Apical cell membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}. Membrane {ECO:0000269PubMed:21976599}; Multi-pass membrane protein {ECO:0000269PubMed:21976599}. Note=Localized in sperm membranes. Midpiece of sperm tail. Colocalizes with CFTR at the midpiece of sperm tail.

Disease Associations

Tissue Specificity

Expressed in spermatogenic cells. {ECO:0000269PubMed:21976599}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008271	secondary active sulfate transmembrane transporter activity
GO:0015106	bicarbonate transmembrane transporter activity
GO:0015108	chloride transmembrane transporter activity
GO:0015116	sulfate transmembrane transporter activity
GO:0015301	anion:anion antiporter activity

Biological Process

GO:0006820	anion transport
GO:0006821	chloride transport
GO:0008272	sulfate transport
GO:0015701	bicarbonate transport
GO:0048240	sperm capacitation
GO:0051454	intracellular pH elevation
GO:0055085	transmembrane transport
GO:0060081	membrane hyperpolarization
GO:0071320	cellular response to cAMP
GO:1902358	sulfate transmembrane transport
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0031526	brush border membrane
GO:0097225	sperm midpiece