InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lims2

Summary

InnateDB Protein

IDBP-133158.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lims2

Protein Name

LIM and senescent cell antigen like domains 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025254

InnateDB Gene

IDBG-133156 (Lims2)

Protein Structure

UniProt Annotation

Function

Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. {ECO:0000250}.

Subcellular Localization

Cell junction, focal adhesion {ECO:0000269PubMed:12651156}. Cell membrane {ECO:0000269PubMed:12651156}; Peripheral membrane protein {ECO:0000269PubMed:12651156}; Cytoplasmic side {ECO:0000269PubMed:12651156}.

Disease Associations

Tissue Specificity

Detected in heart, lung, kidney, liver, urinary bladder, fat, skin, skeletal muscle, uterus, large intestine and testis. {ECO:0000269PubMed:12651156}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0008270	zinc ion binding

Biological Process

GO:0016337	single organismal cell-cell adhesion
GO:0043066	negative regulation of apoptotic process
GO:0045216	cell-cell junction organization
GO:0050680	negative regulation of epithelial cell proliferation
GO:2000178	negative regulation of neural precursor cell proliferation
GO:2000346	negative regulation of hepatocyte proliferation
GO:2001046	positive regulation of integrin-mediated signaling pathway