Version 5.4
Mus musculus Gene: Lims2
Summary
InnateDB Gene IDBG-133156.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lims2
Gene Name LIM and senescent cell antigen like domains 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000024395
Encoded Proteins
IDBP-133158
LIM and senescent cell antigen like domains 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000072163:
This gene encodes a member of a small family of focal adhesion proteins which interacts with ILK (integrin-linked kinase), a protein which effects protein-protein interactions with the extraceullar matrix. The encoded protein has five LIM domains, each domain forming two zinc fingers, which permit interactions which regulate cell shape and migration. A pseudogene of this gene is located on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:31931507-31958619
Strand Forward strand
Band B1
Transcripts
ENSMUST00000025254 ENSMUSP00000025254
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0008270 zinc ion binding
Biological Process
GO:0016337 single organismal cell-cell adhesion
GO:0043066 negative regulation of apoptotic process
GO:0045216 cell-cell junction organization
GO:0050680 negative regulation of epithelial cell proliferation
GO:2000178 negative regulation of neural precursor cell proliferation
GO:2000346 negative regulation of hepatocyte proliferation
GO:2001046 positive regulation of integrin-mediated signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0005925 focal adhesion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000072163
View Gene Order
ENSBTAG00000006262
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_20649
Cell-extracellular matrix interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
REACT_214866
Cell junction organization pathway
REACT_206475
Cell-Cell communication pathway
REACT_213279
Cell-extracellular matrix interactions pathway
KEGG
INOH
PID NCI
ilk_pathway
Integrin-linked kinase signaling
Cross-References
SwissProt Q91XD2
TrEMBL
UniProt Splice Variant
Entrez Gene 225341
UniGene Mm.24551
RefSeq NM_144862 XM_006525845 XM_006525846
OMIM
CCDS CCDS29113
HPRD
IMGT
MGI ID MGI:2385067
MGI Symbol Lims2
EMBL AJ420860 AJ420861 AJ420862 AJ420863 BC010816
GenPept AAH10816 CAD12820
RNA Seq Atlas 225341

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca