Mus musculus Protein: Synj2 | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Protein | IDBP-133246.6 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | Synj2 | ||||||||||||||
Protein Name | synaptojanin 2 | ||||||||||||||
Synonyms | AI481647; mKIAA0348; SJ2; | ||||||||||||||
Species | Mus musculus | ||||||||||||||
Ensembl Protein | ENSMUSP00000079164 | ||||||||||||||
InnateDB Gene | IDBG-133244 (Synj2) | ||||||||||||||
Protein Structure | |||||||||||||||
UniProt Annotation | |||||||||||||||
Function | Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis (By similarity). {ECO:0000250}. | ||||||||||||||
Subcellular Localization | Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. | ||||||||||||||
Disease Associations | |||||||||||||||
Tissue Specificity | Ubiquitously expressed, with the highest levels in heart and brain. Detected in cortex, cerebellum and olfactory bulb. Expressed in the testis. {ECO:0000269PubMed:15722415, ECO:0000269PubMed:9442075}. | ||||||||||||||
Comments | |||||||||||||||
Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||
PDB ID | MGI:1201671 | ||||||||||||||
InterPro |
IPR000300
Inositol polyphosphate-related phosphatase IPR000504 RNA recognition motif domain IPR002013 Synaptojanin, N-terminal IPR005135 Endonuclease/exonuclease/phosphatase IPR015047 Domain of unknown function DUF1866 |
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PFAM |
PF00076
PF02383 PF03372 PF14529 PF08952 |
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PRINTS | |||||||||||||||
PIRSF | |||||||||||||||
SMART |
SM00128
SM00360 |
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TIGRFAMs | |||||||||||||||
Post-translational Modifications | |||||||||||||||
Modification | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | Q9D2G5 | ||||||||||||||
PhosphoSite | PhosphoSite-Q9D2G5 | ||||||||||||||
TrEMBL | D3YZB4 | ||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 20975 | ||||||||||||||
UniGene | Mm.483121 | ||||||||||||||
RefSeq | NP_001106823 | ||||||||||||||
MGI ID | |||||||||||||||
MGI Symbol | Synj2 | ||||||||||||||
OMIM | |||||||||||||||
CCDS | CCDS49932 | ||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | AC154650 AC168063 AF026123 AF041857 AF041858 AF041859 AF041860 AF041861 AF041862 AK019694 AK129122 BC058749 BC060214 | ||||||||||||||
GenPept | AAC33137 AAC40141 AAC40142 AAC40143 AAC40144 AAC40145 AAC40146 AAH58749 AAH60214 BAB31837 BAC97932 | ||||||||||||||