Mus musculus Gene: Synj2
Summary
InnateDB Gene IDBG-133244.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Synj2
Gene Name synaptojanin 2
Synonyms AI481647; mKIAA0348; SJ2;
Species Mus musculus
Ensembl Gene ENSMUSG00000023805
Encoded Proteins
synaptojanin 2
synaptojanin 2
synaptojanin 2
synaptojanin 2
synaptojanin 2
synaptojanin 2
synaptojanin 2
synaptojanin 2
synaptojanin 2
synaptojanin 2
synaptojanin 2
synaptojanin 2
synaptojanin 2
synaptojanin 2
synaptojanin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000078269:
The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibits clathrin-mediated endocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:5941280-6044290
Strand Forward strand
Band A1
Transcripts
ENSMUST00000080283 ENSMUSP00000079164
ENSMUST00000061091 ENSMUSP00000060382
ENSMUST00000115791 ENSMUSP00000111457
ENSMUST00000115790 ENSMUSP00000111456
ENSMUST00000115789 ENSMUSP00000111455
ENSMUST00000115788 ENSMUSP00000111454
ENSMUST00000115787 ENSMUSP00000111453
ENSMUST00000115786 ENSMUSP00000111452
ENSMUST00000115785 ENSMUSP00000111451
ENSMUST00000115784 ENSMUSP00000111450
ENSMUST00000146009 ENSMUSP00000122381
ENSMUST00000134767 ENSMUSP00000138449
ENSMUST00000142409 ENSMUSP00000120006
ENSMUST00000130661
ENSMUST00000154114 ENSMUSP00000122316
ENSMUST00000126881 ENSMUSP00000115371
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0005515 protein binding
GO:0042578 phosphoric ester hydrolase activity
Biological Process
GO:0016311 dephosphorylation
GO:0046856 phosphatidylinositol dephosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Synthesis of PIPs at the plasma membrane pathway
PI Metabolism pathway
Metabolism pathway
Metabolism of lipids and lipoproteins pathway
Phospholipid metabolism pathway
KEGG
Inositol phosphate metabolism pathway
Phosphatidylinositol signaling system pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Synthesis of PIPs at the plasma membrane pathway
PI Metabolism pathway
Phospholipid metabolism pathway
Metabolism pathway
KEGG
Inositol phosphate metabolism pathway
Phosphatidylinositol signaling system pathway
INOH
Inositol phosphate metabolism pathway
PID BIOCARTA
Endocytotic role of ndk phosphins and dynamin [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL F6U4I6
UniProt Splice Variant
Entrez Gene 20975
UniGene Mm.236068 Mm.403830 Mm.483121
RefSeq NM_001113352 NM_011523 NM_001113351 NM_001290698 NM_001113353 XM_006523208 XM_006523212 XM_006523207 XM_006523206 XM_006523202 XM_006523203 XM_006523210 XM_006523204
OMIM
CCDS CCDS49932 CCDS28365 CCDS70757 CCDS49931
HPRD
IMGT
MGI ID MGI:1201671
MGI Symbol Synj2
EMBL AC154650 AC168063
GenPept
RNA Seq Atlas 20975