Version 5.4
Mus musculus Gene: Synj2
Summary
InnateDB Gene IDBG-133244.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Synj2
Gene Name synaptojanin 2
Synonyms AI481647; mKIAA0348; SJ2
Species Mus musculus
Ensembl Gene ENSMUSG00000023805
Encoded Proteins
IDBP-133246
synaptojanin 2
IDBP-133248
synaptojanin 2
IDBP-248855
synaptojanin 2
IDBP-248857
synaptojanin 2
IDBP-248859
synaptojanin 2
IDBP-248861
synaptojanin 2
IDBP-248863
synaptojanin 2
IDBP-248865
synaptojanin 2
IDBP-248867
synaptojanin 2
IDBP-248869
synaptojanin 2
IDBP-541817
synaptojanin 2
IDBP-788078
synaptojanin 2
IDBP-540567
synaptojanin 2
IDBP-532583
synaptojanin 2
IDBP-535877
synaptojanin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000078269:
The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibits clathrin-mediated endocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:5941280-6044290
Strand Forward strand
Band A1
Transcripts
ENSMUST00000080283 ENSMUSP00000079164
ENSMUST00000061091 ENSMUSP00000060382
ENSMUST00000115791 ENSMUSP00000111457
ENSMUST00000115790 ENSMUSP00000111456
ENSMUST00000115789 ENSMUSP00000111455
ENSMUST00000115788 ENSMUSP00000111454
ENSMUST00000115787 ENSMUSP00000111453
ENSMUST00000115786 ENSMUSP00000111452
ENSMUST00000115785 ENSMUSP00000111451
ENSMUST00000115784 ENSMUSP00000111450
ENSMUST00000146009 ENSMUSP00000122381
ENSMUST00000134767 ENSMUSP00000138449
ENSMUST00000142409 ENSMUSP00000120006
ENSMUST00000130661
ENSMUST00000154114 ENSMUSP00000122316
ENSMUST00000126881 ENSMUSP00000115371
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0005515 protein binding
GO:0042578 phosphoric ester hydrolase activity
Biological Process
GO:0016311 dephosphorylation
GO:0046856 phosphatidylinositol dephosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000078269
View Gene Order
ENSBTAG00000000817
Not yet available
Pathways
NETPATH
REACTOME
REACT_198973
Synthesis of PIPs at the plasma membrane pathway
REACT_199016
PI Metabolism pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_188643
Phospholipid metabolism pathway
KEGG
mmu04070
Phosphatidylinositol signaling system pathway
mmu00562
Inositol phosphate metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_121025
Synthesis of PIPs at the plasma membrane pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121175
PI Metabolism pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00562
Inositol phosphate metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
INOH
INOH website
Inositol phosphate metabolism pathway
PID NCI
Cross-References
SwissProt Q9D2G5
TrEMBL D3YWM9
UniProt Splice Variant
Entrez Gene 20975
UniGene Mm.236068 Mm.403830 Mm.483121
RefSeq NM_001113351 NM_011523 XM_006523203 NM_001113352 NM_001113353 NM_001290698 XM_006523202 XM_006523204 XM_006523206 XM_006523207 XM_006523208 XM_006523210 XM_006523212
OMIM
CCDS CCDS28365 CCDS49931 CCDS49932 CCDS70757
HPRD
IMGT
MGI ID MGI:1201671
MGI Symbol Synj2
EMBL AC154650 AC168063 AF026123 AF041857 AF041858 AF041859 AF041860 AF041861 AF041862 AK019694 AK129122 BC058749 BC060214
GenPept AAC33137 AAC40141 AAC40142 AAC40143 AAC40144 AAC40145 AAC40146 AAH58749 AAH60214 BAB31837 BAC97932
RNA Seq Atlas 20975

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca