InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Adam22

Summary

InnateDB Protein

IDBP-133265.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adam22

Protein Name

a disintegrin and metallopeptidase domain 22

Synonyms

2900022I03Rik; AI854032; MDC2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000049120

InnateDB Gene

IDBG-133249 (Adam22)

Protein Structure

UniProt Annotation

Function

Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation (By similarity). Neuronal receptor for LGI1. {ECO:0000250, ECO:0000269PubMed:16990550}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Expressed at high levels in the brain. Strongly expressed in cerebellar granule cells and hippocampus. In spinal cord, expression is restricted to gray matter. {ECO:0000269PubMed:15876356}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0008344	adult locomotory behavior
GO:0014037	Schwann cell differentiation
GO:0022011	myelination in peripheral nervous system
GO:0042063	gliogenesis

Cellular Component

GO:0016021

integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1340046

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001590 Peptidase M12B, ADAM/reprolysin
IPR001762 Blood coagulation inhibitor, Disintegrin
IPR002870 Peptidase M12B, propeptide
IPR006586 ADAM, cysteine-rich

PFAM

PF00008
PF01421
PF00200
PF01562
PF08516

PRINTS

PR00289

PIRSF

SMART

SM00181
SM00050
SM00608

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt