InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Yap1

Summary

InnateDB Protein

IDBP-133277.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Yap1

Protein Name

yes-associated protein 1

Synonyms

AI325207; Yap; Yap65; Yki; Yorkie;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000069554

InnateDB Gene

IDBG-133275 (Yap1)

Protein Structure

UniProt Annotation

Function

Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Both phosphorylation and cell density can regulate its subcellular localization. Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus. At low density, predominantly nuclear and is translocated to the cytoplasm at high density (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoforms lacking the transactivation domain seen in striatal neurons (at protein level). Ubiquitous. Isoform 2 is expressed at higher levels in the neural tissues. In the embryo, it is expressed in brain, eye, and the maxillary and frontonasal components of the primary palate. {ECO:0000269PubMed:12807903, ECO:0000269PubMed:16461361, ECO:0000269PubMed:24462371}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 78 interaction(s) predicted by orthology.

Experimentally validated
Total	49 [view]
Protein-Protein	47 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	78 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001076	RNA polymerase II transcription factor binding transcription factor activity
GO:0003682	chromatin binding
GO:0003713	transcription coactivator activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0044212	transcription regulatory region DNA binding
GO:0070064	proline-rich region binding

Biological Process

GO:0001570	vasculogenesis
GO:0003143	embryonic heart tube morphogenesis
GO:0006366	transcription from RNA polymerase II promoter
GO:0006975	DNA damage induced protein phosphorylation
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0010837	regulation of keratinocyte proliferation
GO:0030216	keratinocyte differentiation
GO:0030857	negative regulation of epithelial cell differentiation
GO:0030903	notochord development
GO:0035019	somatic stem cell maintenance
GO:0035329	hippo signaling
GO:0042127	regulation of cell proliferation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046622	positive regulation of organ growth
GO:0048339	paraxial mesoderm development
GO:0048368	lateral mesoderm development
GO:0060242	contact inhibition
GO:0060828	regulation of canonical Wnt signaling pathway
GO:0071480	cellular response to gamma radiation
GO:0072091	regulation of stem cell proliferation
GO:0072307	regulation of metanephric nephron tubule epithelial cell differentiation
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway