InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Yap1

Summary

InnateDB Gene

IDBG-133275.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Yap1

Gene Name

yes-associated protein 1

Synonyms

AI325207; Yap; Yap65; Yki; Yorkie

Species

Mus musculus

Ensembl Gene

ENSMUSG00000053110

Encoded Proteins

IDBP-133277

yes-associated protein 1

IDBP-133279

yes-associated protein 1

IDBP-620145

yes-associated protein 1

IDBP-620147

yes-associated protein 1

IDBP-620148

yes-associated protein 1

IDBP-620150

yes-associated protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein which binds to the SH3 domain of the Yes proto-oncogene product, a tyrosine kinase. This protein contains a WW domain, consisting of four conserved aromatic amino acids including two tryptophan residues. This conserved WW domain is found in various structural, regulatory and signaling molecules in various species, and may play a role in protein-protein interaction. Following cellular damage, phosphorylation of this encoded protein may suppress apoptosis. This protein may be involved in malignant transformation in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:7931999-8004596

Strand

Reverse strand

Band

Transcripts

ENSMUST00000065353	ENSMUSP00000069554
ENSMUST00000086580	ENSMUSP00000083772
ENSMUST00000174604	ENSMUSP00000134250
ENSMUST00000173264	ENSMUSP00000134237
ENSMUST00000173085	ENSMUSP00000134007
ENSMUST00000174577	ENSMUSP00000133959
ENSMUST00000174127
ENSMUST00000173227
ENSMUST00000172870
ENSMUST00000174300

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 78 interaction(s) predicted by orthology.

Experimentally validated
Total	49 [view]
Protein-Protein	47 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	78 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001076	RNA polymerase II transcription factor binding transcription factor activity
GO:0003682	chromatin binding
GO:0003713	transcription coactivator activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0044212	transcription regulatory region DNA binding
GO:0070064	proline-rich region binding

Biological Process

GO:0001570	vasculogenesis
GO:0003143	embryonic heart tube morphogenesis
GO:0006366	transcription from RNA polymerase II promoter
GO:0006975	DNA damage induced protein phosphorylation
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0010837	regulation of keratinocyte proliferation
GO:0030216	keratinocyte differentiation
GO:0030857	negative regulation of epithelial cell differentiation
GO:0030903	notochord development
GO:0035019	somatic stem cell maintenance
GO:0035329	hippo signaling
GO:0042127	regulation of cell proliferation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046622	positive regulation of organ growth
GO:0048339	paraxial mesoderm development
GO:0048368	lateral mesoderm development
GO:0060242	contact inhibition
GO:0060828	regulation of canonical Wnt signaling pathway
GO:0071480	cellular response to gamma radiation
GO:0072091	regulation of stem cell proliferation
GO:0072307	regulation of metanephric nephron tubule epithelial cell differentiation
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway