InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Map3k2

Summary

InnateDB Protein

IDBP-133556.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Map3k2

Protein Name

mitogen-activated protein kinase kinase kinase 2

Synonyms

9630061B06Rik; AI585793; Mekk2; Mekk2b;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000094326

InnateDB Gene

IDBG-133552 (Map3k2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding

Biological Process

GO:0000165	MAPK cascade
GO:0000186	activation of MAPKK activity
GO:0006468	protein phosphorylation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0071260	cellular response to mechanical stimulus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:1346873

InterPro

IPR000270 Phox/Bem1p
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00564
PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00666
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt