InnateDB Protein
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IDBP-133624.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Cdc42ep2
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Protein Name
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CDC42 effector protein (Rho GTPase binding) 2
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Synonyms
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1110008C05Rik; Borg1; Cep2; D19Bwg1013e;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000059883
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InnateDB Gene
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IDBG-133622 (Cdc42ep2)
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Protein Structure
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Function |
Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner (By similarity). {ECO:0000250}.
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Subcellular Localization |
Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
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Biological Process |
GO:0008360
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regulation of cell shape
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GO:0030036
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actin cytoskeleton organization
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GO:0030838
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positive regulation of actin filament polymerization
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GO:0031274
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positive regulation of pseudopodium assembly
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GO:0032321
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positive regulation of Rho GTPase activity
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Cellular Component |
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PDB ID |
MGI:1929744
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InterPro |
IPR000095
CRIB domain
IPR017363
Cdc42 effector protein 2
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PFAM |
PF00786
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PRINTS |
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PIRSF |
PIRSF038036
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SMART |
SM00285
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TIGRFAMs |
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Modification |
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SwissProt |
Q8JZX9
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PhosphoSite |
PhosphoSite-Q8JZX9
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TrEMBL |
Q9CTH5
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UniProt Splice Variant |
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Entrez Gene |
104252
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UniGene |
Mm.195932
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RefSeq |
NP_081048
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MGI ID |
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MGI Symbol |
Cdc42ep2
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OMIM |
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CCDS |
CCDS29484
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HPRD |
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IMGT |
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EMBL |
AK003562
BC034884
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GenPept |
AAH34884
BAB22858
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