Mus musculus Gene: Cdc42ep2
Summary
InnateDB Gene IDBG-133622.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdc42ep2
Gene Name CDC42 effector protein (Rho GTPase binding) 2
Synonyms 1110008C05Rik; Borg1; Cep2; D19Bwg1013e;
Species Mus musculus
Ensembl Gene ENSMUSG00000045664
Encoded Proteins
CDC42 effector protein (Rho GTPase binding) 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000149798:
CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of CDC42. Coexpression of this protein with CDC42 suggested a role of this protein in actin filament assembly and cell shape control. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:5917556-5924816
Strand Reverse strand
Band A
Transcripts
ENSMUST00000055458 ENSMUSP00000059883
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001515 opioid peptide activity
GO:0005100 Rho GTPase activator activity
GO:0005515 protein binding
GO:0017049 GTP-Rho binding
Biological Process
GO:0008360 regulation of cell shape
GO:0030036 actin cytoskeleton organization
GO:0030838 positive regulation of actin filament polymerization
GO:0031274 positive regulation of pseudopodium assembly
GO:0032321 positive regulation of Rho GTPase activity
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0012505 endomembrane system
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q8JZX9
TrEMBL Q9CTH5
UniProt Splice Variant
Entrez Gene 104252
UniGene Mm.195932
RefSeq NM_026772
OMIM
CCDS CCDS29484
HPRD
IMGT
MGI ID MGI:1929744
MGI Symbol Cdc42ep2
EMBL AK003562 BC034884
GenPept AAH34884 BAB22858
RNA Seq Atlas 104252