Version 5.4
Mus musculus Gene: Cdc42ep2
Summary
InnateDB Gene IDBG-133622.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdc42ep2
Gene Name CDC42 effector protein (Rho GTPase binding) 2
Synonyms 1110008C05Rik; Borg1; Cep2; D19Bwg1013e
Species Mus musculus
Ensembl Gene ENSMUSG00000045664
Encoded Proteins
IDBP-133624
CDC42 effector protein (Rho GTPase binding) 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000149798:
CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of CDC42. Coexpression of this protein with CDC42 suggested a role of this protein in actin filament assembly and cell shape control. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:5917556-5924816
Strand Reverse strand
Band A
Transcripts
ENSMUST00000055458 ENSMUSP00000059883
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001515 opioid peptide activity
GO:0005100 Rho GTPase activator activity
GO:0005515 protein binding
GO:0017049 GTP-Rho binding
Biological Process
GO:0008360 regulation of cell shape
GO:0030036 actin cytoskeleton organization
GO:0030838 positive regulation of actin filament polymerization
GO:0031274 positive regulation of pseudopodium assembly
GO:0032321 positive regulation of Rho GTPase activity
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0012505 endomembrane system
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000149798
View Gene Order
ENSBTAG00000032089
Not yet available
Cross-References
SwissProt Q8JZX9
TrEMBL Q9CTH5
UniProt Splice Variant
Entrez Gene 104252
UniGene Mm.195932
RefSeq NM_026772
OMIM
CCDS CCDS29484
HPRD
IMGT
MGI ID MGI:1929744
MGI Symbol Cdc42ep2
EMBL AK003562 BC034884
GenPept AAH34884 BAB22858
RNA Seq Atlas 104252

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca