InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kdm6a

Summary

InnateDB Protein

IDBP-133898.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kdm6a

Protein Name

lysine (K)-specific demethylase 6A

Synonyms

Utx;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000061539

InnateDB Gene

IDBG-133896 (Kdm6a)

Protein Structure

UniProt Annotation

Function

Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in brain, heart and spleen.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding
GO:0051213	dioxygenase activity
GO:0071558	histone demethylase activity (H3-K27 specific)

Biological Process

GO:0001701	in utero embryonic development
GO:0001843	neural tube closure
GO:0003007	heart morphogenesis
GO:0003016	respiratory system process
GO:0007507	heart development
GO:0010468	regulation of gene expression
GO:0021915	neural tube development
GO:0032525	somite rostral/caudal axis specification
GO:0035264	multicellular organism growth
GO:0048333	mesodermal cell differentiation
GO:0048568	embryonic organ development
GO:0048570	notochord morphogenesis
GO:0055114	oxidation-reduction process
GO:0060070	canonical Wnt signaling pathway
GO:0071557	histone H3-K27 demethylation
GO:0072358	cardiovascular system development