InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Kdm6a

Summary

InnateDB Gene

IDBG-133896.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kdm6a

Gene Name

lysine (K)-specific demethylase 6A

Synonyms

Utx

Species

Mus musculus

Ensembl Gene

ENSMUSG00000037369

Encoded Proteins

IDBP-133898

lysine (K)-specific demethylase 6A

IDBP-133900

lysine (K)-specific demethylase 6A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147050:
This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3. [provided by RefSeq, Nov 2009]
This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:18162575-18279936

Strand

Forward strand

Band

A1.2

Transcripts

ENSMUST00000052368	ENSMUSP00000061539
ENSMUST00000044484	ENSMUSP00000045862
ENSMUST00000130978
ENSMUST00000155161

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding
GO:0051213	dioxygenase activity
GO:0071558	histone demethylase activity (H3-K27 specific)

Biological Process

GO:0001701	in utero embryonic development
GO:0001843	neural tube closure
GO:0003007	heart morphogenesis
GO:0003016	respiratory system process
GO:0007507	heart development
GO:0010468	regulation of gene expression
GO:0021915	neural tube development
GO:0032525	somite rostral/caudal axis specification
GO:0035264	multicellular organism growth
GO:0048333	mesodermal cell differentiation
GO:0048568	embryonic organ development
GO:0048570	notochord morphogenesis
GO:0055114	oxidation-reduction process
GO:0060070	canonical Wnt signaling pathway
GO:0071557	histone H3-K27 demethylation
GO:0072358	cardiovascular system development

Cellular Component

GO:0005634	nucleus
GO:0035097	histone methyltransferase complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000147050

View Gene Order

ENSBTAG00000003740

Not yet available

Pathways

NETPATH

REACTOME

REACT_218274

Chromatin organization pathway

REACT_256030

HDMs demethylate histones pathway

REACT_202766

Chromatin modifying enzymes pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_228178

HDMs demethylate histones pathway

REACT_172623

Chromatin organization pathway

REACT_172633

Chromatin modifying enzymes pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.257498 Mm.411937 Mm.417709 Mm.471789

RefSeq

NM_009483 XM_006527598

OMIM

CCDS

CCDS30037

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas