InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kdm4d

Summary

InnateDB Protein

IDBP-134413.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kdm4d

Protein Name

lysine (K)-specific demethylase 4D

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000061632

InnateDB Gene

IDBG-134411 (Kdm4d)

Protein Structure

UniProt Annotation

Function

Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys- 9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00537}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0046872	metal ion binding
GO:0051213	dioxygenase activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0033169	histone H3-K9 demethylation
GO:0055114	oxidation-reduction process