InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lamp1

Summary

InnateDB Protein

IDBP-134724.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lamp1

Protein Name

lysosomal-associated membrane protein 1

Synonyms

AI196048; CD107a; Lamp-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033824

InnateDB Gene

IDBG-134722 (Lamp1)

Protein Structure

UniProt Annotation

Function

Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome {ECO:0000250}. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane. Colocalizes with OSBPL1A at the late endosome (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding

Biological Process

GO:0006914	autophagy
GO:0007283	spermatogenesis
GO:0008626	granzyme-mediated apoptotic signaling pathway
GO:0043323	positive regulation of natural killer cell degranulation
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity
GO:0048102	autophagic cell death
GO:0050821	protein stabilization
GO:0072594	establishment of protein localization to organelle
GO:0090160	Golgi to lysosome transport
GO:1902513	regulation of organelle transport along microtubule

Cellular Component

GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005768	endosome
GO:0005770	late endosome
GO:0005771	multivesicular body
GO:0005773	vacuole
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030425	dendrite
GO:0031410	cytoplasmic vesicle
GO:0031982	vesicle
GO:0042383	sarcolemma
GO:0042470	melanosome
GO:0043025	neuronal cell body
GO:0044194	cytolytic granule
GO:0061474	phagolysosome membrane
GO:0070062	extracellular vesicular exosome
GO:0097208	alveolar lamellar body