InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc2a2

Summary

InnateDB Protein

IDBP-135096.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc2a2

Protein Name

solute carrier family 2 (facilitated glucose transporter), member 2

Synonyms

AI266973; Glut-2; Glut2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029240

InnateDB Gene

IDBG-135094 (Slc2a2)

Protein Structure

UniProt Annotation

Function

Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

In embryo, expressed in endoderm layer of yolk sac and liver primordium. {ECO:0000269PubMed:1289053}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005355	glucose transmembrane transporter activity
GO:0022857	transmembrane transporter activity
GO:0022891	substrate-specific transmembrane transporter activity
GO:0033300	dehydroascorbic acid transporter activity
GO:0055056	D-glucose transmembrane transporter activity

Biological Process

GO:0006810	transport
GO:0008643	carbohydrate transport
GO:0015758	glucose transport
GO:0031018	endocrine pancreas development
GO:0055085	transmembrane transport
GO:0070837	dehydroascorbic acid transport

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005903	brush border
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1095438

InterPro

IPR002440 Glucose transporter, type 2 (GLUT2)
IPR002666 Reduced folate carrier
IPR003663 Sugar/inositol transporter
IPR005828 General substrate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF01770
PF00083
PF07690

PRINTS

PR01191
PR00171

PIRSF

PIRSF028739

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt