Mus musculus Gene: Slc2a2
Summary
InnateDB Gene IDBG-135094.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc2a2
Gene Name solute carrier family 2 (facilitated glucose transporter), member 2
Synonyms AI266973; Glut-2; Glut2;
Species Mus musculus
Ensembl Gene ENSMUSG00000027690
Encoded Proteins
solute carrier family 2 (facilitated glucose transporter), member 2
solute carrier family 2 (facilitated glucose transporter), member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163581:
Glucose transporter 2 isoform is an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. It mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. [provided by RefSeq, Jul 2008]
This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:28697903-28728356
Strand Forward strand
Band A3
Transcripts
ENSMUST00000029240 ENSMUSP00000029240
ENSMUST00000163536 ENSMUSP00000131046
ENSMUST00000169047
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005355 glucose transmembrane transporter activity
GO:0022857 transmembrane transporter activity
GO:0022891 substrate-specific transmembrane transporter activity
GO:0033300 dehydroascorbic acid transporter activity
GO:0055056 D-glucose transmembrane transporter activity
Biological Process
GO:0006810 transport
GO:0008643 carbohydrate transport
GO:0015758 glucose transport
GO:0031018 endocrine pancreas development
GO:0055085 transmembrane transport
GO:0070837 dehydroascorbic acid transport
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005903 brush border
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Disease pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
SLC-mediated transmembrane transport pathway
Integration of energy metabolism pathway
Metabolism pathway
Regulation of insulin secretion pathway
Glucose transport pathway
Transmembrane transport of small molecules pathway
Hexose transport pathway
Glycogen storage diseases pathway
Regulation of gene expression in beta cells pathway
Developmental Biology pathway
Regulation of beta-cell development pathway
Facilitative Na+-independent glucose transporters pathway
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
KEGG
Type II diabetes mellitus pathway
Maturity onset diabetes of the young pathway
Carbohydrate digestion and absorption pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Integration of energy metabolism pathway
Transmembrane transport of small molecules pathway
Developmental Biology pathway
Myoclonic epilepsy of Lafora pathway
Facilitative Na+-independent glucose transporters pathway
Glucose transport pathway
Hexose transport pathway
Metabolism of carbohydrates pathway
Regulation of beta-cell development pathway
Regulation of gene expression in beta cells pathway
Regulation of insulin secretion pathway
Metabolism pathway
SLC-mediated transmembrane transport pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
Disease pathway
Glycogen storage diseases pathway
Metabolism of carbohydrates pathway
SLC-mediated transmembrane transport pathway
Hexose transport pathway
Regulation of insulin secretion pathway
Myoclonic epilepsy of Lafora pathway
Integration of energy metabolism pathway
Transmembrane transport of small molecules pathway
Regulation of gene expression in beta cells pathway
Regulation of beta-cell development pathway
Facilitative Na+-independent glucose transporters pathway
Glucose transport pathway
Glycogen storage diseases pathway
Metabolism pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
Disease pathway
Developmental Biology pathway
KEGG
Type II diabetes mellitus pathway
Maturity onset diabetes of the young pathway
Carbohydrate digestion and absorption pathway
INOH
PID BIOCARTA
PID NCI
FOXA2 and FOXA3 transcription factor networks
Cross-References
SwissProt P14246
TrEMBL E9PXR7
UniProt Splice Variant
Entrez Gene 20526
UniGene Mm.18443 Mm.399808
RefSeq NM_031197
OMIM
CCDS CCDS50880
HPRD
IMGT
MGI ID MGI:1095438
MGI Symbol Slc2a2
EMBL AC121268 AK005068 AK165430 BC034675 S77926 X15684 X16986 X78722
GenPept AAB20847 AAH34675 BAB23792 BAE38184 CAA33719 CAA34855 CAA55368
RNA Seq Atlas 20526