InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Araf

Summary

InnateDB Protein

IDBP-135381.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Araf

Protein Name

v-raf murine sarcoma 3611 viral oncogene homolog

Synonyms

1200013E08Rik; A-Raf; Araf1; AW495444;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000001155

InnateDB Gene

IDBG-135379 (Araf)

Protein Structure

UniProt Annotation

Function

Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	44 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005057	receptor signaling protein activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0032006	regulation of TOR signaling
GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0035556	intracellular signal transduction
GO:0043066	negative regulation of apoptotic process

Cellular Component

GO:0005739

mitochondrion

Protein Structure and Domains

PDB ID

MGI:88065

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003116 Raf-like Ras-binding
IPR011009 Protein kinase-like domain
IPR020454 Diacylglycerol/phorbol-ester binding
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR029071 Ubiquitin-related domain

PFAM

PF00069
PF07714
PF00130
PF02196

PRINTS

PR00109
PR00008

PIRSF

SMART

SM00109
SM00220
SM00455
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt